3rd International conference on Brain disorders & Neurodegeneration

A typical mature neuron has a network of hundreds if not thousands of branches connecting it to other neurons , and these connections are what determine brain function . These connections are also built up slowly over years and decades of experience and reinforcement signalling. In order to divide itself, a neuron would have to retract all these connections back into its main cell body , thus losing all its accumulated normal function. The two new daughter cells would have no connections and would thus be useless. Re-establishing such a complex network of connections to restore normal function is a staggeringly difficult task, and even if it could be done there would be a time gap in which the function would not be present. And a single mistake in rewriting can have far reaching consequences, such as seizures. Over evolutionary time as brains got ever more complex it just became more advantageous to maintain individual neurons for as long as possible, keeping their con...

Neuropathy sufferers now have a new, minimally invasive therapy option: stem cell treatment for neuropathy. Stem cell therapy for neuropathy is an alternative, revolutionary approach to relieving your neuropathy pain and symptoms . A stem cell's primary function is to repair and regenerate damaged tissue . Most patients feel no improvement for at least 3 weeks and possible 6-8 weeks. Once you feel improvement, you will notice continued improvement expanding over 6 months. What is the recovery like after a stem cell procedure? There may be some mild soreness in the joint for up to a week after the injection. Go to my Profile and you can find all Neuropathy material there... Reference: Martha Mitchell

For best results together with your own brain training you'll specialise in a couple of main points: Awareness: Once you are often increasingly conscious of your own experiences, reactions, and limitation, you'll be ready to guide your own brain training regimen. Listening to the days you grind to a halt, and therefore the experiences that you simply find the foremost upsetting will guide you better than the other diagnosis. Anger, frustration, and irritation are fantastic signposts pointing you to the exercises which will benefit you. Make it up:   You don’t need to join a gym to urge exercise and you don’t need to use professional services to exercise your brain. Do things that you simply think are hard. If you struggle with speechmaking, do that. If you're a terrible reader, do that. If you hate math, do that. Therapeutic exercise is about doing the items that are hard. Dig deeper:   Don’t have a look for reasons to elucidate your weaknesses. Sometim...

After binding of the ligand, the receptor tyrosine kinase (RTK) autophosphorylates Tyrosine -> activates GRB2 -> SOS -> RAS -> downstream kinase -> transcription factors. Think  anabolic / growth factors  - Insulin, IGF-1, FGF, PDGF, and EGF Nonreceptor tyrosine kinase receptors dimerizes -> recruits JAK -> JAK cross-phosphorylate dimer -> activate STAT and dimerize it -> STAT translocates into nucleus and activates transcription. The hormones are mostly related to immunity. Think  acidophils and cytokines . A good mnemonic is PIGG (L) ET: Prolactin, Immunomodulators (cytokine, IL-2, Il-6, IFN), GH, G-CSF, Erythropoietin and Thromobopoietin The key conceptual difference here is RTK has  intrinsic  TK activity and nRTK needs to recruit JAK to have kinase activity. Reference: Kayee Tong

Alzheimer’s disease usually is not diagnosed in the early stages, even in people who visit their primary care doctors with memory complaints. ·          People and their families generally underreport the symptoms. ·          They may confuse them with normal signs of aging. ·          The symptoms may emerge so gradually that the person affected doesn’t recognize them. ·          The person may be aware of some symptoms but go to great lengths to conceal them. Recognizing symptoms early is crucial because medication to control symptoms is most effective in the early stages of the disease and early diagnosis allows the individual and his or her family members to plan for the future. If you or a loved one is experiencing any of the following symptoms, contact a physician. Memory loss that disrupts daily life. ...

Dementia is a category of disease, not a diagnosis. It indicates that there are problems with cognition severe enough to interfere with daily function. AD is the most common form of dementia. It is characterized by plaques (beta amyloid) that form outside the neuron, and tangles (tau tangles) that form inside the neuron. The neuron subsequently dies, and the surround structures of the brain are affected until the brain can no longer sustain life. There are three forms of AD, and one subtype. Lewy Body Dementia is the third most commonly occurring dementia. Lewy bodies are deposits of alpha-synuclein in the brain. If those deposits form and stay in the substantia nigra, it is Parkinson’s disease. If they form elsewhere in the brain, it is LBD. LBD is characterized by psychiatric features, and does not progress in the same manner as AD (which has a fairly predictable progression). LBD is misdiagnosed about 25% of the time. Having an accurate diagnosis for this form of dementia is ...

Well, I must admit that  Diagnosing ADHD  isn’t just about reading symptoms and reading relate able posts. It’s much beyond that. It  requires a psychologist and various tests and behavioural observation over a period of time. It could often have overlapping symptoms with Bipolar Disorder, depression and anxiety . Psychiatrists diagnose attention-deficit hyperactivity disorder (ADHD) if the individual displays six or more of the following symptoms of inattention or six or more symptoms of hyperactivity and impulsivity. The signs must occur often and be present for at least six months to a degree that is maladaptive and inconsistent with the person’s developmental level. ADHD involves two sets of symptoms: inattention and a combination of hyperactive and impulsive behaviours- INATTENTION ·          Fails to give close attention to details or makes careless mistakes in schoolwork, work or other activities ·   ...