What is the difference between non receptor tyrosine kinase and receptor tyrosine kinase?


After binding of the ligand, the receptor tyrosine kinase (RTK) auto phosphorylates Tyrosine -> activates GRB2 -> SOS -> RAS -> downstream kinase -> transcription factors. Think anabolic/growth factors - Insulin, IGF-1, FGF, PDGF, EGF
Non receptor tyrosine kinase receptors dimerizes -> recruits JAK -> JAK cross-phosphorylate dimer -> activate STAT and dimerize it -> STAT translocates into nucleus and activates transcription. The hormones are mostly related to immunity. Think acidophils and cytokines. A good mnemonic is PIGG (L) ET: Prolactin, Immunomodulators (cytokine, IL-2, Il-6, IFN), GH, G-CSF, Erythropoietin and Thromobopoietin
The key conceptual difference here is RTK has intrinsic TK activity and nRTK needs to recruit JAK to have kinase activity.
Here is an image that gives you a side-by-side comparison:

Reference: Kayee Tong

Comments

Post a Comment

Popular posts from this blog

3rd International conference on Brain disorders & Neurodegeneration

3rd International conference on Brain disorders & Neurodegeneration April 21 -22, 2020 | Paris, France 3rd International Conference on Brain Disorders & Neurodegeneration is organised by Larix International and scheduled on April 21-22, 2020 in Paris, France.  Neuroscience 2020 aims to collect eminent scientists, analysis students, notable medical specialist, and educationists and professionals to specific their views on the most recent technologies, trends, and considerations in Neuroscience. It focuses on addressing the constant effort being created by soul and students to enhance the present and inventing novel technologies for future. The conference will address the problems being visaged by surgeons and patients and therefore the impact of neurology within the world. Neuroscience 2020 conference provides a platform for organisations, companies, associations, societies, establishments, statutory bodies and alternative authorities and people fascinated by...
Read more

Why can't brain cells reproduce?

Image
A typical mature neuron has a network of hundreds if not thousands of branches connecting it to other neurons , and these connections are what determine brain function . These connections are also built up slowly over years and decades of experience and reinforcement signalling. In order to divide itself, a neuron would have to retract all these connections back into its main cell body , thus losing all its accumulated normal function. The two new daughter cells would have no connections and would thus be useless. Re-establishing such a complex network of connections to restore normal function is a staggeringly difficult task, and even if it could be done there would be a time gap in which the function would not be present. And a single mistake in rewriting can have far reaching consequences, such as seizures. Over evolutionary time as brains got ever more complex it just became more advantageous to maintain individual neurons for as long as possible, keeping their con...
Read more

Neuroscience: Yes, Brain Training Actually Can Work When Done Correctly?

Image
For best results together with your own brain training you'll specialise in a couple of main points: Awareness: Once you are often increasingly conscious of your own experiences, reactions, and limitation, you'll be ready to guide your own brain training regimen. Listening to the days you grind to a halt, and therefore the experiences that you simply find the foremost upsetting will guide you better than the other diagnosis. Anger, frustration, and irritation are fantastic signposts pointing you to the exercises which will benefit you. Make it up:   You don’t need to join a gym to urge exercise and you don’t need to use professional services to exercise your brain. Do things that you simply think are hard. If you struggle with speechmaking, do that. If you're a terrible reader, do that. If you hate math, do that. Therapeutic exercise is about doing the items that are hard. Dig deeper:   Don’t have a look for reasons to elucidate your weaknesses. Sometim...
Read more